Managing multiple vendors is a thing of the past! Biosearch satisfies all of your requirements to accelerate assay development from conception to commercialization. We conjugate a diverse assortment of labels to custom-synthesized oligos and blend into formulations to your specifications. In addition to FAM, TET, HEX, JOE, etc., Biosearch also offers its own vibrant fluorophores and dark quenchers for flexible licensing programs.

Proprietary Fluorophores and Quenchers

Black Hole Quencher (BHQ) Dyes

• True "dark" quenchers with no native fluorescence
• Extinguishes fluorescence through FRET and static quenching
• Quenches across the spectrum, even past 700 nm!

CAL Fluor, Quasar, and Pulsar Dyes

• Perfect complement to the BHQ
• High performing amidites for automated probe synthesis
• Emit fluorescence from 500-700 nm to match the optics of every qPCR thermal cycler
• 5’-, 3’-, and internal labeling to support all probe formats

Technical Excellence in Synthesis

Through the cooperative efforts of our chemical manufacturing, custom synthesis, and product development facilities, Biosearch can provide:

• Bulk Qualified Reagents
• Individual Oligo Components
• Packaged Assay Sets

Biosearch manufactures the oligo conjugates that fuel a wide variety of instrument platforms such as qPCR thermal cyclers and Luminex®-based systems. Probe and primer formats that we commonly synthesize for real-time PCR include:

• TaqMan®
• Molecular Beacons™
• Scorpions™
• Amplifluor®
• Plexors™

Our repertoire also includes a large selection of oligonucleotide modifications such as active esters, amidities, spacers, linkers, biotins, and more. Click here for our list of modifications. Biosearch's widespread experience also includes the synthesis of RNA, RNA-DNA hybrids, and other complex and rare specialty bases.

With technical experience and state-of-the-art instruments, Biosearch can coordinate your component production through every phase of product development, whether it is for R&D or production, with synthesis scales ranging from 25 nmol to several mmol.



Request an e-brochure for details about our purification, formulation and delivery options.

Quality Systems Management

Our production facility is governed by extensive quailty documentation such as fully tested and validated SOPs and Certificates of Analysis. Depending on the product, Biosearch’s standard QC release methods include:

• Final mass determination by Electrospray Ionization Mass Spectrometry (ESI-MS)
• Physical inspection of product
• Fluorescent HPLC detection, signal to noise ratio
• Reverse Phase HPLC
• Anion Exchange HPLC
• Final concentration verification
• Gravimetric confirmation of aliquot volumes

For intricate, large scale projects, clients can customize QC procedures to their specifications such as implementing unique functional testing.

Partner with Biosearch

Biosearch has dedicated project managers to attend to the development and launch of your IVD product. We are happy to provide you services in assay design, custom synthesis, manufacturing, and kit assembly that are scalable to suit your needs. Our assistance will allow you time to focus on developing your market niche rather than building underutilized or unnecessary manufacturing capacity.

Licensing Programs

If you are interested in utilizing BHQ, CAL Fluor, Quasar, or Pulsar 650 dyes in ASRs or using probes containing Biosearch’s Intellectual Property in commercial kits, services, or products, Biosearch offers flexible and packaged licensing programs that are tailored to the terms of your project. We actively out-license access to 4 Biosearch patent families:

• 1) Black Hole Quencher dyes, U.S. Patent No. 7,019,127 and continuations;
• 2) CAL Fluor dyes, U.S. Patent No. 7,344,701;
• 3) Quasar dyes, U.S. Patent Application No. US2005/0214833A1;
• 4) Pulsar 650 dyes, U.S. Patent Application No. US2004/0146895A1.

We will gladly assist you in determining what licensing is necessary for your particular product. Please contact Marc Beal marcb@biosearchtech.com or licensing@biosearchtech.com with any related questions.

Our friendly and professional customer service at Biosearch is here to ensure that your product progresses seamlessly towards commercialization. We also have an experienced team of chemists and molecular biologists who are available to assist you in the composition and formulation of your oligonucleotide-based assay, or for supplying raw materials manufactured to your stringent specifications. For questions about the services we offer for molecular diagnostics, please e-mail info@biosearchtech.com or call us: 1.800.GENOME.1 (436.6631).